Research Data Leeds Repository

Dataset associated with 'Quantification of Ebola virus replication kinetics in vitro'

Citation

Liao, Laura E. and Carruthers, Jonathan and Smither, Sophie J. and Weller, Simon A. and Williamson, Diane and Laws, Thomas R. and García-Dorival, Isabel and Hiscox, Julian and Holder, Benjamin P. and Beauchemin, Catherine A. A. and Perelson, Alan S. and López-García, Martín and Lythe, Grant and Barr, John and Molina-París, Carmen, CL4 Virology Team (2020) Dataset associated with 'Quantification of Ebola virus replication kinetics in vitro'. University of Leeds. [Dataset] https://doi.org/10.5518/915¹

Dataset description

This dataset is associated with ‘Quantification of Ebola virus replication kinetics in vitro’. In the paper, a mathematical model is developed to describe the replication of Ebola virus in Vero cells. The model is parametrised using measurements of total and infectious extracellular virus at three different multiplicities of infection. The results provide insights into the distribution of time an infected cell spends in the eclipse phase (the period between infection and the start of virus production), as well as the rate at which infectious virions lose infectivity. Here, we provide all the experimental results necessary to parametrise the mathematical model.

Additional information:	Content includes material subject to Dstl Crown Copyright [2020] This is the dataset of an open access article under the Open Government Licence (OGL)
Keywords:	Ebola virus, mathematical modelling, virus replication kinetics, mathematical immunology
Divisions:	Faculty of Biological Sciences > School of Molecular and Cellular Biology2 Faculty of Engineering and Physical Sciences > School of Mathematics3
Related resources:	Location Type https://eprints.whiterose.ac.uk/167283/4 Publication https://arxiv.org/abs/2010.098985 Publication https://doi.org/10.1371/journal.pcbi.10083756 Publication
License:	Open Government Licence 3.0 (OGL 3.0)
Date deposited:	23 Oct 2020 14:05
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/7627
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Liao, Laura E. https://orcid.org/0000-0001-6069-26338 Los Alamos National Laboratory https://ror.org/01e41cf67 ror Carruthers, Jonathan https://orcid.org/0000-0002-1372-32549 University of Leeds https://ror.org/024mrxd33 ror Smither, Sophie J. https://orcid.org/0000-0002-7835-358110 Defence Science and Technology Laboratory https://ror.org/04jswqb94 ror Weller, Simon A. https://orcid.org/0000-0001-9286-299111 Defence Science and Technology Laboratory https://ror.org/04jswqb94 ror Williamson, Diane https://orcid.org/0000-0002-0322-597212 Defence Science and Technology Laboratory https://ror.org/04jswqb94 ror Laws, Thomas R. https://orcid.org/0000-0002-0142-916213 Defence Science and Technology Laboratory https://ror.org/04jswqb94 ror García-Dorival, Isabel https://orcid.org/0000-0002-5654-566214 University of Liverpool https://ror.org/04xs57h96 ror Hiscox, Julian https://orcid.org/0000-0002-6582-027515 University of Liverpool https://ror.org/04xs57h96 ror Holder, Benjamin P. https://orcid.org/0000-0003-3492-057X16 Grand Valley State University https://ror.org/001m1hv61 ror Beauchemin, Catherine A. A. https://orcid.org/0000-0003-0599-006917 Toronto Metropolitan University https://ror.org/05g13zd79 ror RIKEN https://ror.org/01sjwvz98 ror Perelson, Alan S. https://orcid.org/0000-0002-2455-000218 Los Alamos National Laboratory https://ror.org/01e41cf67 ror López-García, Martín https://orcid.org/0000-0003-3833-859519 University of Leeds https://ror.org/024mrxd33 ror Lythe, Grant https://orcid.org/0000-0001-7966-557120 University of Leeds https://ror.org/024mrxd33 ror Barr, John https://orcid.org/0000-0002-9035-203921 University of Leeds https://ror.org/024mrxd33 ror Molina-París, Carmen https://orcid.org/0000-0001-9828-673722 University of Leeds https://ror.org/024mrxd33 ror Corporate creators: CL4 Virology Team Type of data: Dataset Publication date: 2020 Resource language: English Metadata language: English Publisher: University of Leeds Last Modified: 08 Jan 2025 11:59

Files

Documentation

README.txt [621B] 23 README.txt [621B] 24 README.txt [621B] 25 Security: Anyone File name: README.txt26 Content type: Documentation Mime-Type: text/plain File size: 621B

Data

Standard curve calibration [9kB] 27 Standard curve calibration [9kB] 28 Standard curve calibration [9kB] 29 Security: Anyone File name: count-to-Ct.xlsx30 Content type: Data Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Open Government Licence 3.0 (OGL 3.0) File size: 9kB

MOI 0.1, 1 and 5 total virus [10kB] 31 MOI 0.1, 1 and 5 total virus [10kB] 32 MOI 0.1, 1 and 5 total virus [10kB] 33 Security: Anyone File name: mc-Ct.xlsx34 Content type: Data Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Open Government Licence 3.0 (OGL 3.0) File size: 10kB

MOI 0.1, 1 and 5 infectious virus [10kB] 35 MOI 0.1, 1 and 5 infectious virus [10kB] 36 MOI 0.1, 1 and 5 infectious virus [10kB] 37 Security: Anyone File name: mc-tcid.xlsx38 Content type: Data Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Open Government Licence 3.0 (OGL 3.0) File size: 10kB

Mock-yield assay total virus [8kB] 39 Mock-yield assay total virus [8kB] 40 Mock-yield assay total virus [8kB] 41 Security: Anyone File name: my-Ct.xlsx42 Content type: Data Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Open Government Licence 3.0 (OGL 3.0) File size: 8kB

Mock-yield assay infectious virus [9kB] 43 Mock-yield assay infectious virus [9kB] 44 Mock-yield assay infectious virus [9kB] 45 Security: Anyone File name: my-tcid.xlsx46 Content type: Data Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Open Government Licence 3.0 (OGL 3.0) File size: 9kB

• 1. https://doi.org/10.5518/915
• 2. https://archive.researchdata.leeds.ac.uk/view/divisions/SMCB/
• 3. https://archive.researchdata.leeds.ac.uk/view/divisions/SM/
• 4. https://eprints.whiterose.ac.uk/167283/
• 5. https://arxiv.org/abs/2010.09898
• 6. https://doi.org/10.1371/journal.pcbi.1008375
• 7. https://archive.researchdata.leeds.ac.uk/id/eprint/762
• 8. https://orcid.org/0000-0001-6069-2633
• 9. https://orcid.org/0000-0002-1372-3254
• 10. https://orcid.org/0000-0002-7835-3581
• 11. https://orcid.org/0000-0001-9286-2991
• 12. https://orcid.org/0000-0002-0322-5972
• 13. https://orcid.org/0000-0002-0142-9162
• 14. https://orcid.org/0000-0002-5654-5662
• 15. https://orcid.org/0000-0002-6582-0275
• 16. https://orcid.org/0000-0003-3492-057X
• 17. https://orcid.org/0000-0003-0599-0069
• 18. https://orcid.org/0000-0002-2455-0002
• 19. https://orcid.org/0000-0003-3833-8595
• 20. https://orcid.org/0000-0001-7966-5571
• 21. https://orcid.org/0000-0002-9035-2039
• 22. https://orcid.org/0000-0001-9828-6737
• 23. https://archive.researchdata.leeds.ac.uk/762/6/README.txt
• 24. https://archive.researchdata.leeds.ac.uk/762/6/README.txt
• 25. https://archive.researchdata.leeds.ac.uk/762/6/README.txt
• 26. https://archive.researchdata.leeds.ac.uk/762/6/README.txt
• 27. https://archive.researchdata.leeds.ac.uk/762/1/count-to-Ct.xlsx
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• 30. https://archive.researchdata.leeds.ac.uk/762/1/count-to-Ct.xlsx
• 31. https://archive.researchdata.leeds.ac.uk/762/2/mc-Ct.xlsx
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• 33. https://archive.researchdata.leeds.ac.uk/762/2/mc-Ct.xlsx
• 34. https://archive.researchdata.leeds.ac.uk/762/2/mc-Ct.xlsx
• 35. https://archive.researchdata.leeds.ac.uk/762/3/mc-tcid.xlsx
• 36. https://archive.researchdata.leeds.ac.uk/762/3/mc-tcid.xlsx
• 37. https://archive.researchdata.leeds.ac.uk/762/3/mc-tcid.xlsx
• 38. https://archive.researchdata.leeds.ac.uk/762/3/mc-tcid.xlsx
• 39. https://archive.researchdata.leeds.ac.uk/762/4/my-Ct.xlsx
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• 41. https://archive.researchdata.leeds.ac.uk/762/4/my-Ct.xlsx
• 42. https://archive.researchdata.leeds.ac.uk/762/4/my-Ct.xlsx
• 43. https://archive.researchdata.leeds.ac.uk/762/5/my-tcid.xlsx
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• 45. https://archive.researchdata.leeds.ac.uk/762/5/my-tcid.xlsx
• 46. https://archive.researchdata.leeds.ac.uk/762/5/my-tcid.xlsx