Research Data Leeds Repository

Citation

Fowler, Jake (2026) Investigating The Evolutionary Origins Of Calcium Signalling Proteins – Supplementary data. University of Leeds. [Dataset] https://doi.org/10.5518/1703

Dataset description

This dataset is the supplementary material for the thesis: INVESTIGATING THE EVOLUTIONARY ORIGINS OF CALCIUM SIGNALLING PROTEINS. The data is divided into four parent folders which represent three results chapters and a future work chapter. Chapter 2 is a method development chapter using Aspartate 1-Decaboxylase (PanD) as a target. Chapters 3 and 4 are individual bioinformatics-driven case studies of proteins that are involved in calcium signalling, namely ionotropic glutamate receptors (iGluRs) and calmodulin (CaM) respectively. Chapter 2 contains scripts used throughout the project in the bioinformatics pipeline, and phylogenetic results. Chapter 3 contains phylogenetic analysis results for iGluRs as well as Molecular Dynamics and Statistical Coupling Analysis results. Chapter 4 contains phylogenetic analysis results for CaM and experimental results using various Nuclear Magnetic Resonance techniques for structural elucidation.

Keywords:	Bioinformatics; Evolution; Gene Transfer; Phylogenetics; Structural Biology; Homology; Microbiology; Proteins; Calcium; Signalling; Neurotransmission; Alignment; Molecular Dynamics
Divisions:	Faculty of Engineering and Physical Sciences > School of Chemistry
Related resources:	Location Type https://etheses.whiterose.ac.uk/id/eprint/36773/ Ethesis
License:	Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Date deposited:	25 Oct 2026 23:27
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/1656
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Fowler, Jake https://orcid.org/0000-0003-2823-5453 University of Leeds https://ror.org/024mrxd33 ror Type of data: Dataset Publication date: 25 October 2026 Resource language: English Metadata language: English Publisher: University of Leeds Last Modified: 25 Oct 2026 23:41

Files

Data

2_PanD.zip [51MB] 2_PanD.zip [51MB] 2_PanD.zip [51MB] Security: Anyone File name: 2_PanD.zip Content type: Data Mime-Type: application/zip License: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) File size: 51MB

3_Glutamate.zip [208MB] 3_Glutamate.zip [208MB] 3_Glutamate.zip [208MB] Security: Anyone File name: 3_Glutamate.zip Content type: Data Mime-Type: application/zip License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) File size: 208MB

5_Future_Work.zip [14MB] 5_Future_Work.zip [14MB] 5_Future_Work.zip [14MB] Security: Anyone File name: 5_Future_Work.zip Content type: Data Mime-Type: application/zip License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) File size: 14MB