Research Data Leeds Repository

Citation

Bourn, Matthew D. and Batchelor, Damien V. B. and Ingram, Nicola and McLaughlan, James R. and Coletta, P. Louise and Evans, Stephen D. and Peyman, Sally A. (2020) High-throughput Microfluidics for Evaluating Microbubble Enhanced Delivery of Cancer Therapeutics in Spheroid Cultures - Dataset. University of Leeds. [Dataset] https://doi.org/10.5518/777

Dataset description

This collection of datasets provides the data used to create the graphs throughout the associated manuscript. Data for spheroid trapping efficiency (fig 1b), fluid flow rates (fig 2c) and spheroid viabilities and diameters (figs 3b, 4c, 5b and 6c) have all been provided.

Subjects:	F000 - Physical sciences > F300 - Physics
Divisions:	Faculty of Engineering and Physical Sciences > School of Electronic and Electrical Engineering Faculty of Engineering and Physical Sciences > School of Physics and Astronomy
Related resources:	Location Type https://doi.org/10.1016/j.jconrel.2020.06.011 Publication https://eprints.whiterose.ac.uk/161863/ Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	16 Jun 2020 11:32
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/692
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Bourn, Matthew D. https://orcid.org/0000-0002-5620-4550 University of Leeds https://ror.org/024mrxd33 ror Batchelor, Damien V. B. https://orcid.org/0000-0001-6489-9578 University of Leeds https://ror.org/024mrxd33 ror Ingram, Nicola https://orcid.org/0000-0001-5274-8502 University of Leeds https://ror.org/024mrxd33 ror McLaughlan, James R. https://orcid.org/0000-0001-5795-4372 University of Leeds https://ror.org/024mrxd33 ror Coletta, P. Louise https://orcid.org/0000-0002-3858-6073 University of Leeds https://ror.org/024mrxd33 ror Evans, Stephen D. https://orcid.org/0000-0001-8342-5335 University of Leeds https://ror.org/024mrxd33 ror Peyman, Sally A. https://orcid.org/0000-0002-1600-5100 University of Leeds https://ror.org/024mrxd33 ror Type of data: Dataset Research funders: EPSRC, EPSRC, MRC Grant numbers: EP/P023266/1, EP/S002069/1, MR/M009084/1 Publication date: 2020 Resource language: English Metadata language: English Publisher: University of Leeds Contact email: s.peyman@leeds.ac.uk Last Modified: 20 Dec 2024 14:32

Files

Data

Flow Rate Data [367kB] Flow Rate Data [367kB] Flow Rate Data [367kB] Security: Anyone File name: Flow_Rate_Data.xlsx Content type: Data Description: Theorectical and measured flow rates for a range of reservoir height differences Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 367kB

Spheroid Diameters [40kB] Spheroid Diameters [40kB] Spheroid Diameters [40kB] Security: Anyone File name: Spheroid_Diameters.xlsx Content type: Data Description: List of the diameter of every spheroid loaded onto each chip in each experiment Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 40kB

Spheroid Viability Data [30kB] Spheroid Viability Data [30kB] Spheroid Viability Data [30kB] Security: Anyone File name: Spheroid_Viability_Data_Compiled.xlsx Content type: Data Description: Plate read luminescence values recorded for every experiment. Experiment numbers correspond with numbers in 'Spheroid Diameters'. Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 30kB

Trapping Efficiency Data [11kB] Trapping Efficiency Data [11kB] Trapping Efficiency Data [11kB] Security: Anyone File name: Trap_Efficiency_Data.xlsx Content type: Data Description: Percentage trapping efficiency for differing spheroid diameters Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 11kB

MB Size Distribution and Destruction [10kB] MB Size Distribution and Destruction [10kB] MB Size Distribution and Destruction [10kB] Security: Anyone File name: MB_Size_Distribution_and_Destruction.xlsx Content type: Data Description: This file contains the microbubble size distribution data used to plot supplementary figure 1. Data for on-chip MB concentrations before and after US are also included, which were used to plot supplementary figure 6 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 10kB

Spheroid off-chip viability data [11kB] Spheroid off-chip viability data [11kB] Spheroid off-chip viability data [11kB] Security: Anyone File name: Spheroid_off-chip_viability_data.xlsx Content type: Data Description: This contains ATP viability data from off-chip experiments used to plot supplementary figure 5 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 11kB

Spheroid Shear Stress [70kB] Spheroid Shear Stress [70kB] Spheroid Shear Stress [70kB] Security: Anyone File name: Spheroid_Shear_Stress.xlsx Content type: Data Description: This contains the data extracted from ansys flow simulations for shear stress on spheroids in traps - used to plot supplementry figure 4 (graph) Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 70kB