Research Data Leeds Repository

Citation

Anastasiou, Antonios and Brown, Andrew and Jha, Animesh (2019) Drug loading capacity of microporous β-pyrophosphate crystals - dataset. University of Leeds. [Dataset] https://doi.org/10.5518/568

Dataset description

Periodontitis and peri-implantitis are two characteristic examples where bacterial infections compromise the healing of dental tissues. Drug eluting scaffolds are a potential solution to this problem but their fabrication requires suitable biomaterials with significant drug loading capacity and regenerative potential to support new tissue formation. With this aim, porous β-pyrophosphate crystals having a micro-pore area of 2.59 m2/g and an average pore diameter of 65 nm, have been obtained by the heat treatment of brushite (at 780 oC). To demonstrate the drug loading potential of the mineral, experiments with chloramphenicol have been conducted. After tests with four common bacteria, the drug loaded mineral was shown to have enhanced antibacterial properties, particularly towards E. coli (74% growth inhibition) and S. aureus (48% growth inhibition). Taking into account β-pyrophosphate’s significant role in hard tissue mineralisation and the capability to tailor crystal micro-porosity characteristics by controlled heat treatment, the mineral can be considered as an ideal biomaterial for localised drug delivery in dental applications.

Subjects:	A000 - Medicine & dentistry > A200 - Pre-clinical dentistry H000 - Engineering > H100 - General engineering > H160 - Bioengineering, biomedical engineering & clinical engineering
Divisions:	Faculty of Engineering and Physical Sciences > School of Chemical and Process Engineering
Related resources:	Location Type https://doi.org/10.1016/j.matdes.2019.107661 Publication https://eprints.whiterose.ac.uk/144687/ Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	22 May 2019 09:42
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/527
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Anastasiou, Antonios https://orcid.org/0000-0003-3858-9431 University of Leeds https://ror.org/024mrxd33 ror Brown, Andrew https://orcid.org/0000-0001-9692-2154 University of Leeds https://ror.org/024mrxd33 ror Jha, Animesh https://orcid.org/0000-0003-3150-5645 University of Leeds https://ror.org/024mrxd33 ror Type of data: Dataset Research funders: EU Marie Curie, Engineering and Physical Sciences Research Council Collection period: Date from Date to 1 February 2016 30 October 2018 Grant numbers: 660147, EP/N00941X/1 Publication date: 2019 Resource language: English Metadata language: English Research project title: PRe-Facto Publisher: University of Leeds Contact email: a.anastasiou@leeds.ac.uk Last Modified: 29 Oct 2024 10:51

Files

Data

FTIR drug loaded minerals [325kB] FTIR drug loaded minerals [325kB] FTIR drug loaded minerals [325kB] Security: Anyone File name: FTIR_drug_loaded_minerals.opju Content type: Data License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 325kB

sta brushite [469kB] sta brushite [469kB] sta brushite [469kB] Security: Anyone File name: sta_brushite.opj Content type: Data License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 469kB

SEM images [3MB] SEM images [3MB] SEM images [3MB] Security: Anyone File name: SEM_and_TEM_images.pptx Content type: Data Description: images Mime-Type: application/vnd.openxmlformats-officedocument.presentationml.presentation License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 3MB

BJH 1 (Brushite) [49kB] BJH 1 (Brushite) [49kB] BJH 1 (Brushite) [49kB] Security: Anyone File name: BJH_1_Brushite.xls Content type: Data Mime-Type: application/vnd.ms-excel License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 49kB

BJH 2 (Monetite) [49kB] BJH 2 (Monetite) [49kB] BJH 2 (Monetite) [49kB] Security: Anyone File name: BJH_2_Monetite.xls Content type: Data Mime-Type: application/vnd.ms-excel License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 49kB

BJH 3 (Pyrophosphate) [50kB] BJH 3 (Pyrophosphate) [50kB] BJH 3 (Pyrophosphate) [50kB] Security: Anyone File name: BJH_3_Pyrophosphate.xls Content type: Data Mime-Type: application/vnd.ms-excel License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 50kB

ISO 1 (Brushite) [44kB] ISO 1 (Brushite) [44kB] ISO 1 (Brushite) [44kB] Security: Anyone File name: Iso_1_Brushite.xls Content type: Data Mime-Type: application/vnd.ms-excel License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 44kB

ISO 2 (Monetite) [45kB] ISO 2 (Monetite) [45kB] ISO 2 (Monetite) [45kB] Security: Anyone File name: Iso_2_Monetite.xls Content type: Data Mime-Type: application/vnd.ms-excel License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 45kB

ISO 3 (Pyrophosphate) [45kB] ISO 3 (Pyrophosphate) [45kB] ISO 3 (Pyrophosphate) [45kB] Security: Anyone File name: Iso_3_Pyrophosphate.xls Content type: Data Mime-Type: application/vnd.ms-excel License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 45kB