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Supplemental material of manuscript entitled: Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England

Mebrahtu, Teumzghi F. and Morgan, Ann W. and Keeley, Adam and Baxter, Paul D. and Stewart, Paul M. and Pujades-Rodriguez, Mar (2019) Supplemental material of manuscript entitled: Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England. University of Leeds. [Dataset] https://doi.org/10.5518/545

Dataset description

We conducted a population-based, record-linkage, open-cohort study to quantify dose-related risks of adrenal insufficiency, Cushing’s syndrome and death in adults with six chronic inflammatory diseases commonly treated with oral glucocorticoids. We found high glucocorticoid dose-dependent increased risks of adrenal dysfunction and death but low absolute risks, indicating potential under-diagnosis in primary care and the need to increase physician and patient awareness and education about the risks of adrenal dysfunction induced by glucocorticoids.

Keywords: Adrenal dysfunction, adrenal insufficiency, cohort studies, Cushing’s syndrome, electronic health records, England, glucocorticoids, mortality, population-based study, toxicity, safety, UK
Subjects: A000 - Medicine & dentistry > A300 - Clinical medicine
B000 - Subjects allied to medicine > B200 - Pharmacology, toxicology & pharmacy > B210 - Pharmacology
Divisions: Faculty of Medicine and Health > School of Medicine > Leeds Institute of Biomedical Clinical Sciences (LIBCS)
Faculty of Medicine and Health > School of Medicine > Leeds Institute of Health Sciences (LIHS)
Related resources:
LocationType
https://doi.org/10.1210/jc.2019-00153Publication
License: Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited: 18 Apr 2019 09:58
URI: https://archive.researchdata.leeds.ac.uk/id/eprint/510

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