Research Data Leeds Repository

Characteristics of low concentration SDS decellularised human donor aortic and pulmonary valved conduits.

Citation

Ingham, Eileen and Vafaee, Tayyebeh and Thomas, Daniel and Desai, Amisha and Jennings, Louise and Berry, Helen and Rooney, Paul and Kearney, John and Fisher, John (2016) Characteristics of low concentration SDS decellularised human donor aortic and pulmonary valved conduits. University of Leeds. [Dataset] https://doi.org/10.5518/42¹

Dataset description

Data on the biological and biomechanical properties of human donor aortic and pulmonary cardiac valves before and after decellularisation: biomechanical testing data (ultimate tensile strength, failure strain, Young's modulus); DNA, collagen and GAG content; in vitro biocompatibility.

Keywords:	Cardiac valves, aortic valve, pulmonary valve, allogeneic valve, decellularisation
Subjects:	A000 - Medicine & dentistry > A100 - Pre-clinical medicine2 H000 - Engineering > H100 - General engineering > H160 - Bioengineering, biomedical engineering & clinical engineering > H162 - Biomechanics (including fluid & solid mechanics)3 C000 - Biological sciences > C900 - Others in Biological Sciences > C910 - Applied biological sciences4 H000 - Engineering > H100 - General engineering > H160 - Bioengineering, biomedical engineering & clinical engineering5 H000 - Engineering > H100 - General engineering > H160 - Bioengineering, biomedical engineering & clinical engineering > H161 - Biomaterials6 C000 - Biological sciences > C100 - Biology > C110 - Applied biology7 H000 - Engineering > H100 - General engineering > H160 - Bioengineering, biomedical engineering & clinical engineering > H165 - Tissue engineering & regenerative medicine8
Divisions:	Faculty of Biological Sciences > Institute of Medical and Biological Engineering Faculty of Engineering and Physical Sciences > Institute of Medical and Biological Engineering Faculty of Engineering and Physical Sciences > School of Mechanical Engineering > Institute of Medical and Biological Engineering9
Related resources:	Location Type https://doi.org/10.1002/term.239110 Publication https://eprints.whiterose.ac.uk/109976/11 Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	24 Mar 2016 12:18
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/3512
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Ingham, Eileen https://orcid.org/0000-0002-9757-304513 University of Leeds https://ror.org/024mrxd33 ror Vafaee, Tayyebeh https://orcid.org/0000-0002-0733-980314 University of Leeds https://ror.org/024mrxd33 ror Thomas, Daniel https://orcid.org/0000-0001-5584-911415 University of Leeds https://ror.org/024mrxd33 ror Desai, Amisha https://orcid.org/0000-0001-8611-995816 University of Leeds https://ror.org/024mrxd33 ror Jennings, Louise https://orcid.org/0000-0003-1446-451117 University of Leeds https://ror.org/024mrxd33 ror Berry, Helen https://orcid.org/0000-0003-2426-188118 University of Leeds https://ror.org/024mrxd33 ror Rooney, Paul https://orcid.org/0000-0003-3724-571719 NHS Blood and Transplant https://ror.org/0227qpa16 ror Kearney, John NHS Blood and Transplant https://ror.org/0227qpa16 ror Fisher, John https://orcid.org/0000-0003-3833-370020 University of Leeds https://ror.org/024mrxd33 ror Type of data: Dataset Research funders: Wellcome Trust, EPSRC, Regener8 Grant numbers: WT088908/z/09/z Publication date: 2016 Resource language: English Metadata language: English Research project title: Engineering solutions for an ageing population with musculoskeletal & cardiovascular disease. 50 more years after 50., Acellular allogeneic valves Publisher: University of Leeds Copyright holders: University of Leeds Contact email: E.ingham@leeds.ac.uk21 Last Modified: 22 Aug 2024 13:31

Files

Documentation

Readme [402B] 22 Readme [402B] 23 Readme [402B] 24 Security: Anyone File name: Readme.txt25 Content type: Documentation Description: Description of dataset Mime-Type: text/plain File size: 402B

Data

DNA raw data and analysis [58kB] 26 DNA raw data and analysis [58kB] 27 DNA raw data and analysis [58kB] 28 Security: Anyone File name: DNA_Analysis_Data.xlsx29 Content type: Data Description: Details of tissue weights, solution volumes and analysis for the DNA assay Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 58kB

GAG raw data and analysis [44kB] 30 GAG raw data and analysis [44kB] 31 GAG raw data and analysis [44kB] 32 Security: Anyone File name: Glycosaminoglycan_GAG_Assay_Data.xlsx33 Content type: Data Description: Details of tissue weights, solution volumes and analysis for the GAG assay. Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 44kB

Hydroxyproline raw data and analysis [41kB] 34 Hydroxyproline raw data and analysis [41kB] 35 Hydroxyproline raw data and analysis [41kB] 36 Security: Anyone File name: Hydroxyproline_HXP_Assay_Data.xlsx37 Content type: Data Description: Details of tissue weights, solution volumes and analysis for the hydroxyproline assay, Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 41kB

Extract assay BHK [26kB] 38 Extract assay BHK [26kB] 39 Extract assay BHK [26kB] 40 Security: Anyone File name: BHK_Extract_analysis.xlsx41 Content type: Data Description: Details of tissue weights, solution volumes and analysis for the extract cytotoxicity data with BHK cells Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 26kB

Extract assay 3T3 [25kB] 42 Extract assay 3T3 [25kB] 43 Extract assay 3T3 [25kB] 44 Security: Anyone File name: 3T3_Extract_analysis.xlsx45 Content type: Data Description: Details of tissue weights, solution volumes and analysis for the extract cytotoxicity data with 3T3 cells Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 25kB

Biomechanical data and analysis [874kB] 46 Biomechanical data and analysis [874kB] 47 Biomechanical data and analysis [874kB] 48 Security: Anyone File name: Biomechanics_Data.docx49 Content type: Data Description: Details of the uniaxial tensile testing of the cardiac valve tissues and analysis of data Mime-Type: application/vnd.openxmlformats-officedocument.wordprocessingml.document File size: 874kB

Contact cytotoxicity data [39MB] 50 Contact cytotoxicity data [39MB] 51 Contact cytotoxicity data [39MB] 52 Security: Anyone File name: Contact_cytotoxicity_images.zip53 Content type: Data Description: Images of the contact cytotoxicity assayswith BHK and 3T3 cells Mime-Type: application/zip File size: 39MB

• 1. https://doi.org/10.5518/42
• 2. https://archive.researchdata.leeds.ac.uk/view/subjects/A100.html
• 3. https://archive.researchdata.leeds.ac.uk/view/subjects/H162.html
• 4. https://archive.researchdata.leeds.ac.uk/view/subjects/C910.html
• 5. https://archive.researchdata.leeds.ac.uk/view/subjects/H160.html
• 6. https://archive.researchdata.leeds.ac.uk/view/subjects/H161.html
• 7. https://archive.researchdata.leeds.ac.uk/view/subjects/C110.html
• 8. https://archive.researchdata.leeds.ac.uk/view/subjects/H165.html
• 9. https://archive.researchdata.leeds.ac.uk/view/divisions/IMBE/
• 10. https://doi.org/10.1002/term.2391
• 11. https://eprints.whiterose.ac.uk/109976/
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• 13. https://orcid.org/0000-0002-9757-3045
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• 15. https://orcid.org/0000-0001-5584-9114
• 16. https://orcid.org/0000-0001-8611-9958
• 17. https://orcid.org/0000-0003-1446-4511
• 18. https://orcid.org/0000-0003-2426-1881
• 19. https://orcid.org/0000-0003-3724-5717
• 20. https://orcid.org/0000-0003-3833-3700
• 21. mailto:E.ingham@leeds.ac.uk
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• 29. https://archive.researchdata.leeds.ac.uk/35/2/DNA_Analysis_Data.xlsx
• 30. https://archive.researchdata.leeds.ac.uk/35/3/Glycosaminoglycan_GAG_Assay_Data.xlsx
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• 32. https://archive.researchdata.leeds.ac.uk/35/3/Glycosaminoglycan_GAG_Assay_Data.xlsx
• 33. https://archive.researchdata.leeds.ac.uk/35/3/Glycosaminoglycan_GAG_Assay_Data.xlsx
• 34. https://archive.researchdata.leeds.ac.uk/35/4/Hydroxyproline_HXP_Assay_Data.xlsx
• 35. https://archive.researchdata.leeds.ac.uk/35/4/Hydroxyproline_HXP_Assay_Data.xlsx
• 36. https://archive.researchdata.leeds.ac.uk/35/4/Hydroxyproline_HXP_Assay_Data.xlsx
• 37. https://archive.researchdata.leeds.ac.uk/35/4/Hydroxyproline_HXP_Assay_Data.xlsx
• 38. https://archive.researchdata.leeds.ac.uk/35/5/BHK_Extract_analysis.xlsx
• 39. https://archive.researchdata.leeds.ac.uk/35/5/BHK_Extract_analysis.xlsx
• 40. https://archive.researchdata.leeds.ac.uk/35/5/BHK_Extract_analysis.xlsx
• 41. https://archive.researchdata.leeds.ac.uk/35/5/BHK_Extract_analysis.xlsx
• 42. https://archive.researchdata.leeds.ac.uk/35/6/3T3_Extract_analysis.xlsx
• 43. https://archive.researchdata.leeds.ac.uk/35/6/3T3_Extract_analysis.xlsx
• 44. https://archive.researchdata.leeds.ac.uk/35/6/3T3_Extract_analysis.xlsx
• 45. https://archive.researchdata.leeds.ac.uk/35/6/3T3_Extract_analysis.xlsx
• 46. https://archive.researchdata.leeds.ac.uk/35/7/Biomechanics_Data.docx
• 47. https://archive.researchdata.leeds.ac.uk/35/7/Biomechanics_Data.docx
• 48. https://archive.researchdata.leeds.ac.uk/35/7/Biomechanics_Data.docx
• 49. https://archive.researchdata.leeds.ac.uk/35/7/Biomechanics_Data.docx
• 50. https://archive.researchdata.leeds.ac.uk/35/8/Contact_cytotoxicity_images.zip
• 51. https://archive.researchdata.leeds.ac.uk/35/8/Contact_cytotoxicity_images.zip
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• 53. https://archive.researchdata.leeds.ac.uk/35/8/Contact_cytotoxicity_images.zip