Research Data Leeds Repository

Data associated with 'On-chip preparation of nanoscale contrast agents toward high-resolution ultrasound imaging'

Peyman, Sally A. (2016) Data associated with 'On-chip preparation of nanoscale contrast agents toward high-resolution ultrasound imaging'. University of Leeds. [Dataset] https://doi.org/10.5518/33

Dataset description

This data set supports images and graphs in a the manuscript listed above. In brief: a new microfluidic method for the generation of sub-micron sized lipid stabilised particles containing perfluorocarbon (PFC). The nanoparticles are produced in a unique atomisation-like flow regime at high production rates, in excess of 106 particles / s and at high concentration, typically > 1011 particles / mL. The average particle diameter appears to be around 100-200 nm. These particles, suspected of being a mix of liquid and gaseous C4F10 due to Laplace pressure, then phase convert into nanometer sized bubbles on the application of US. In vitro ultrasound characterisation from these nanoparticle populations showed strong backscattering compared to aqueous filled liposomes of a similar size. The nanoparticles were stable upon injection and gave excellent contrast enhancement when used for in vivo imaging, compared to microbubbles with an equivalent shell composition.

Keywords:	microbubble, nanobubble, imaging, drug delivery
Subjects:	F000 - Physical sciences > F300 - Physics > F350 - Medical physics F000 - Physical sciences > F300 - Physics > F380 - Acoustics C000 - Biological sciences > C700 - Molecular biology, biophysics & biochemistry > C770 - Biophysical science
Divisions:	Faculty of Engineering and Physical Sciences > School of Physics and Astronomy
Related resources:	Location Type http://doi.org/10.1039/C5LC01394A Publication http://eprints.whiterose.ac.uk/96341/ Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	18 Mar 2016 17:28
URI:	http://archive.researchdata.leeds.ac.uk/id/eprint/34
Additional details Additional details Creators: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Peyman, Sally A. https://orcid.org/0000-0002-1600-5100 University of Leeds https://doi.org/10.13039/501100000777 crossref Type of data: Dataset Research funders: EPSRC Grant numbers: EP/K023845/1 Publication date: 2016 Resource language: English Metadata language: English Research project title: Hydrophobic delivery Publisher: University of Leeds Contact Email Address: s.peyman@leeds.ac.uk Last Modified: 10 Apr 2018 15:53

Files

Data

Data for figure 2b [11kB] Data for figure 2b [11kB] Data for figure 2b [11kB] Visible to: Anyone File name: data_for_figure_2b.xlsx Content type: Data Description: Microbubble size and concentration data from optical measurements Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 11kB

Data for figure 3 [10kB] Data for figure 3 [10kB] Data for figure 3 [10kB] Visible to: Anyone File name: data_for_figure_3.xlsx Content type: Data Description: Nanobubble size and concentration data from NanoSight Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 10kB

Data for figure 4a [16kB] Data for figure 4a [16kB] Data for figure 4a [16kB] Visible to: Anyone File name: data_for_figure_4a.xlsx Content type: Data Description: Nanobubble size change on temperature from Zetasizer Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 16kB

Data for figure 5 [10kB] Data for figure 5 [10kB] Data for figure 5 [10kB] Visible to: Anyone File name: data_for_figure_5.xlsx Content type: Data Description: Nanobubble size and concentration stability from qNano Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 10kB

Data for figure 6a [46kB] Data for figure 6a [46kB] Data for figure 6a [46kB] Visible to: Anyone File name: data_for_figure_6a.xls Content type: Data Description: Ultrasound backscatter signal from nanobubbles and liposomes Mime-Type: application/vnd.ms-excel File size: 46kB

Data for figure 6b [1MB] Data for figure 6b [1MB] Data for figure 6b [1MB] Visible to: Anyone File name: data_for_figure_6b.xlsx Content type: Data Description: Distribution of calculated resonance frequencies for nanobubbles with different shell parameters Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 1MB

Raw Images 1-13 [7MB] Raw Images 1-13 [7MB] Raw Images 1-13 [7MB] Visible to: Anyone File name: raw_images_1_13.zip Content type: Data Mime-Type: application/zip File size: 7MB