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Data associated with 'On-chip preparation of nanoscale contrast agents toward high-resolution ultrasound imaging'

Peyman, Sally A. (2016) Data associated with 'On-chip preparation of nanoscale contrast agents toward high-resolution ultrasound imaging'. University of Leeds. [Dataset] https://doi.org/10.5518/33

Dataset description

This data set supports images and graphs in a the manuscript listed above. In brief: a new microfluidic method for the generation of sub-micron sized lipid stabilised particles containing perfluorocarbon (PFC). The nanoparticles are produced in a unique atomisation-like flow regime at high production rates, in excess of 106 particles / s and at high concentration, typically > 1011 particles / mL. The average particle diameter appears to be around 100-200 nm. These particles, suspected of being a mix of liquid and gaseous C4F10 due to Laplace pressure, then phase convert into nanometer sized bubbles on the application of US. In vitro ultrasound characterisation from these nanoparticle populations showed strong backscattering compared to aqueous filled liposomes of a similar size. The nanoparticles were stable upon injection and gave excellent contrast enhancement when used for in vivo imaging, compared to microbubbles with an equivalent shell composition.

Keywords: microbubble, nanobubble, imaging, drug delivery
Subjects: F000 - Physical sciences > F300 - Physics > F350 - Medical physics
F000 - Physical sciences > F300 - Physics > F380 - Acoustics
C000 - Biological sciences > C700 - Molecular biology, biophysics & biochemistry > C770 - Biophysical science
Divisions: Faculty of Mathematics and Physical Sciences > School of Physics and Astronomy
Related resources:
LocationType
http://doi.org/10.1039/C5LC01394APublication
http://eprints.whiterose.ac.uk/96341/Publication
License: Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited: 18 Mar 2016 17:28
URI: http://archive.researchdata.leeds.ac.uk/id/eprint/34

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