Research Data Leeds Repository
Data associated with 'On-chip preparation of nanoscale contrast agents toward high-resolution ultrasound imaging'
Citation
Peyman, Sally A. (2016) Data associated with 'On-chip preparation of nanoscale contrast agents toward high-resolution ultrasound imaging'. University of Leeds. [Dataset] https://doi.org/10.5518/33
Dataset description
This data set supports images and graphs in a the manuscript listed above. In brief: a new microfluidic method for the generation of sub-micron sized lipid stabilised particles containing perfluorocarbon (PFC). The nanoparticles are produced in a unique atomisation-like flow regime at high production rates, in excess of 106 particles / s and at high concentration, typically > 1011 particles / mL. The average particle diameter appears to be around 100-200 nm. These particles, suspected of being a mix of liquid and gaseous C4F10 due to Laplace pressure, then phase convert into nanometer sized bubbles on the application of US. In vitro ultrasound characterisation from these nanoparticle populations showed strong backscattering compared to aqueous filled liposomes of a similar size. The nanoparticles were stable upon injection and gave excellent contrast enhancement when used for in vivo imaging, compared to microbubbles with an equivalent shell composition.
Keywords: | microbubble, nanobubble, imaging, drug delivery | ||||||
---|---|---|---|---|---|---|---|
Subjects: | F000 - Physical sciences > F300 - Physics > F350 - Medical physics F000 - Physical sciences > F300 - Physics > F380 - Acoustics C000 - Biological sciences > C700 - Molecular biology, biophysics & biochemistry > C770 - Biophysical science |
||||||
Divisions: | Faculty of Engineering and Physical Sciences > School of Physics and Astronomy | ||||||
Related resources: |
|
||||||
License: | Creative Commons Attribution 4.0 International (CC BY 4.0) | ||||||
Date deposited: | 18 Mar 2016 17:28 | ||||||
URI: | https://archive.researchdata.leeds.ac.uk/id/eprint/34 | ||||||