Research Data Leeds Repository

Citation

West, Emma and Samson, Adel (2024) mRNAseq to investigate the immunological effects of intrahepatic artery delivery of TG6002 in combination with oral 5-fluorocytosine - dataset. University of Leeds. [Dataset] https://doi.org/10.5518/1593

Dataset description

A phase 1 study of TG6002 vaccinia virus infusion via the hepatic artery in combination with oral 5-flurocytosine to colorectal cancer patients with liver metastases. Patient PBMCs were isolated from peripheral blood samples taken throughout treatment. mRNA sequencing was performed to investigate the immune response to combination treatment. Differential gene expression analysis revealed an association with viral dose; cluster analysis highlighted several pathways relevant to immune responses, type I interferon signalling and specific response to virus.

Additional information:	This dataset is held in the Restricted Access Data Repository, RADAR. To request access, please click the link under ‘Related resources’. You will be prompted to complete a request form including your intended use of the dataset. You will then receive an initial response to your request within 10 working days.
Subjects:	C000 - Biological sciences > C500 - Microbiology
Divisions:	Faculty of Medicine and Health > School of Medicine
Related resources:	Location Type https://radar.researchdata.leeds.ac.uk/62/ Dataset https://doi.org/10.1101/2024.07.30.24311046 Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	28 Oct 2024 15:37
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/1336
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type West, Emma https://orcid.org/0000-0001-7449-120X University of Leeds https://ror.org/024mrxd33 ror Samson, Adel https://orcid.org/0000-0002-3081-7850 University of Leeds https://ror.org/024mrxd33 ror Type of data: Dataset Research funders: CRUK Grant numbers: 29039 Publication date: 2024 Resource language: English Metadata language: English Publisher: University of Leeds Contact email: e.j.west@leeds.ac.uk Last Modified: 03 Dec 2024 12:12

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