Research Data Leeds Repository

Supplemental material of manuscript entitled: Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England

Citation

Mebrahtu, Teumzghi F. and Morgan, Ann W. and Keeley, Adam and Baxter, Paul D. and Stewart, Paul M. and Pujades-Rodriguez, Mar (2019) Supplemental material of manuscript entitled: Dose dependency of iatrogenic glucocorticoid excess and adrenal insufficiency and mortality: a cohort study in England. University of Leeds. [Dataset] https://doi.org/10.5518/545¹

Dataset description

We conducted a population-based, record-linkage, open-cohort study to quantify dose-related risks of adrenal insufficiency, Cushing’s syndrome and death in adults with six chronic inflammatory diseases commonly treated with oral glucocorticoids. We found high glucocorticoid dose-dependent increased risks of adrenal dysfunction and death but low absolute risks, indicating potential under-diagnosis in primary care and the need to increase physician and patient awareness and education about the risks of adrenal dysfunction induced by glucocorticoids.

Keywords:	Adrenal dysfunction, adrenal insufficiency, cohort studies, Cushing’s syndrome, electronic health records, England, glucocorticoids, mortality, population-based study, toxicity, safety, UK
Subjects:	A000 - Medicine & dentistry > A300 - Clinical medicine2 B000 - Subjects allied to medicine > B200 - Pharmacology, toxicology & pharmacy > B210 - Pharmacology3
Divisions:	Faculty of Medicine and Health > School of Medicine > Leeds Institute of Biomedical Clinical Sciences (LIBCS)4 Faculty of Medicine and Health > School of Medicine > Leeds Institute of Health Sciences (LIHS)5
Related resources:	Location Type https://doi.org/10.1210/jc.2019-001536 Publication https://eprints.whiterose.ac.uk/145124/7 Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	18 Apr 2019 09:58
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/5108
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Mebrahtu, Teumzghi F. https://orcid.org/0000-0003-4821-23049 University of Leeds https://ror.org/024mrxd33 ror Morgan, Ann W. https://orcid.org/0000-0003-1109-624X10 University of Leeds https://ror.org/024mrxd33 ror Keeley, Adam https://orcid.org/0000-0003-4396-054911 University of Leeds https://ror.org/024mrxd33 ror Baxter, Paul D. https://orcid.org/0000-0003-2699-310312 University of Leeds https://ror.org/024mrxd33 ror Stewart, Paul M. https://orcid.org/0000-0002-1749-964013 University of Leeds https://ror.org/024mrxd33 ror Pujades-Rodriguez, Mar https://orcid.org/0000-0002-1375-102814 University of Leeds https://ror.org/024mrxd33 ror Type of data: Dataset Research funders: MRC, NIHR, NIHR, NIHR, ERC Grant numbers: RO-115-2018-1061, RGRMEX 107713, MIC-2016-015, NF-SI-0514-10090, 250271 Publication date: 2019 Resource language: English Metadata language: English Research project title: Medtech and In vitro Diagnostics Co-operatives, Senior Investigator award, PRECORT grant Publisher: University of Leeds Contact email: M.D.M.PujadesRodriguez@leeds.ac.uk15 Last Modified: 28 Oct 2024 15:42

Files

Data

Supplemental material of manuscript entitled: Dose-response and evidence of underdiagnoses of adrenal glucocorticoid adverse events: findings from a population based cohort in England [1MB] 16 Supplemental material of manuscript entitled: Dose-response and evidence of underdiagnoses of adrenal glucocorticoid adverse events: findings from a population based cohort in England [1MB] 17 Supplemental material of manuscript entitled: Dose-response and evidence of underdiagnoses of adrenal glucocorticoid adverse events: findings from a population based cohort in England [1MB] 18 Security: Anyone File name: PujadesRodriguez_Supplement_JCEM_FINAL.docx19 Content type: Data Description: Tables 1 - 14 and Figures 1 - 7 Mime-Type: application/vnd.openxmlformats-officedocument.wordprocessingml.document License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 1MB

• 1. https://doi.org/10.5518/545
• 2. https://archive.researchdata.leeds.ac.uk/view/subjects/A300.html
• 3. https://archive.researchdata.leeds.ac.uk/view/subjects/B210.html
• 4. https://archive.researchdata.leeds.ac.uk/view/divisions/LIBCS/
• 5. https://archive.researchdata.leeds.ac.uk/view/divisions/LIHS/
• 6. https://doi.org/10.1210/jc.2019-00153
• 7. https://eprints.whiterose.ac.uk/145124/
• 8. https://archive.researchdata.leeds.ac.uk/id/eprint/510
• 9. https://orcid.org/0000-0003-4821-2304
• 10. https://orcid.org/0000-0003-1109-624X
• 11. https://orcid.org/0000-0003-4396-0549
• 12. https://orcid.org/0000-0003-2699-3103
• 13. https://orcid.org/0000-0002-1749-9640
• 14. https://orcid.org/0000-0002-1375-1028
• 15. mailto:M.D.M.PujadesRodriguez@leeds.ac.uk
• 16. https://archive.researchdata.leeds.ac.uk/510/1/PujadesRodriguez_Supplement_JCEM_FINAL.docx
• 17. https://archive.researchdata.leeds.ac.uk/510/1/PujadesRodriguez_Supplement_JCEM_FINAL.docx
• 18. https://archive.researchdata.leeds.ac.uk/510/1/PujadesRodriguez_Supplement_JCEM_FINAL.docx
• 19. https://archive.researchdata.leeds.ac.uk/510/1/PujadesRodriguez_Supplement_JCEM_FINAL.docx