Research Data Leeds Repository

Agent-based model of heterogeneous T cell activation in vitro (supplementary material)

Lythe, Grant and Majumdar, Shamik and Molina-Paris, Carmen and Nandi, Dipankar (2020) Agent-based model of heterogeneous T cell activation in vitro (supplementary material). University of Leeds. [Dataset]

Dataset description

We combine modelling and in vitro measurement of T-cell properties at the level of individual cells. Two types of heterogeneity are explicitly simulated: cell-surface marker expression that is time-dependent and varies from cell to cell, and spatial heterogeneity that arises from local influences such as the proximity of IL-2-producing cells. In vitro, the kinetics of the activation of cohorts of CD4+ T cells from 4-6 week-old BALB/c mice was studied, under stimulus with soluble or plate-bound anti-CD3, or a combination of PMA and ionomycin.

Keywords: T cells in vitro, stochastic simulation
Divisions: Faculty of Mathematics and Physical Sciences > School of Mathematics
License: Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited: 17 Oct 2020 07:45





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