Research Data Leeds Repository

Citation

Lythe, Grant and Majumdar, Shamik and Molina-París, Carmen and Nandi, Dipankar (2020) Agent-based model of heterogeneous T cell activation in vitro (supplementary material). University of Leeds. [Dataset] https://doi.org/10.5518/880

Dataset description

We combine modelling and in vitro measurement of T-cell properties at the level of individual cells. Two types of heterogeneity are explicitly simulated: cell-surface marker expression that is time-dependent and varies from cell to cell, and spatial heterogeneity that arises from local influences such as the proximity of IL-2-producing cells. In vitro, the kinetics of the activation of cohorts of CD4+ T cells from 4-6 week-old BALB/c mice was studied, under stimulus with soluble or plate-bound anti-CD3, or a combination of PMA and ionomycin.

Keywords:	T cells in vitro, stochastic simulation
Divisions:	Faculty of Engineering and Physical Sciences > School of Mathematics
Related resources:	Location Type https://doi.org/10.1007/978-3-030-57204-4_14 Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	17 Oct 2020 07:45
URI:	https://archive.researchdata.leeds.ac.uk/id/eprint/758
Additional details Additional details Creators or authors: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Lythe, Grant https://orcid.org/0000-0001-7966-5571 University of Leeds https://ror.org/024mrxd33 ror Majumdar, Shamik https://orcid.org/0000-0002-3458-816X Indian Institute of Science Bangalore https://ror.org/04dese585 ror Molina-París, Carmen https://orcid.org/0000-0001-9828-6737 University of Leeds https://ror.org/024mrxd33 ror Nandi, Dipankar https://orcid.org/0000-0002-5221-9712 Indian Institute of Science Bangalore https://ror.org/04dese585 ror Type of data: Dataset Research funders: European Union FP7 Grant numbers: FP7-PEOPLE-2012-IRSES 317893 Publication date: 2020 Resource language: English Metadata language: English Research project title: Mathematics for Health and Disease Publisher: University of Leeds Contact email: grant@maths.leeds.ac.uk Last Modified: 16 Jul 2024 09:21

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Data

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