1. ABOUT THE DATASET -------------------- Title: Data for "The cassette exons of a-synuclein play distinct roles in membrane remodelling and membrane mediated amyloid formation" Creator(s): Katherine M. Dewison, Pijush Chakraborty, David J. Brockwell*, Sheena E. Radford* Organisation(s): 1. University of Leeds Rights-holder(s):Unless otherwise stated, Copyright 2026 University of Leeds Publication Year: 2026 Description: Dataset for 'The cassette exons of α-synuclein play distinct roles in membrane remodelling and membrane-mediated amyloid formation'. Containing raw data including circular dichroism, NMR, and thioflavin T fluorescence data. Cite as: Dewison, K.M., Chakraborty, P., Brockwell, D. J., and Radford, S. E. (2026): Data for "The cassette exons of α-synuclein play distinct roles in membrane remodelling and membrane-mediated amyloid formation". University of Leeds. [Dataset] https://doi.org/10.5518/1869 Related publication: Dewison, K.M., Chakraborty, P., Brockwell, D. J., and Radford, S. E. (2026) The cassette exons of α-synuclein play distinct roles in membrane remodelling and membrane-mediated amyloid formation. Chemical Science (accepted). Contact: Katherine M. Dewison (fbskdew@leeds.ac.uk), Sheena E. Radford (s.e.radford@leeds.ac.uk) 2. TERMS OF USE --------------- Unless otherwise stated, this dataset is licensed under a Creative Commons Attribution 4.0 International Licence: https://creativecommons.org/licenses/by/4.0/. 3. PROJECT AND FUNDING INFORMATION ---------------------------------- Title: The cassette exons of α-synuclein play distinct roles in membrane remodelling and membrane-mediated amyloid formation Dates: N/A Funding organisation: MRC, Wellcome, Royal Society Grant no.: 094232/Z/10/Z and RSRP/R1/211057 and MR/N013840/1 4. CONTENTS ----------- File listing: Data_fig2 - Fig 2a-d - MRE for aSynFL, D3, D5, D3D5 at varying LPRs Data_fig3 - Fig 3 and SI Fig 2 - intensity ratios in the presence or absence of DMPS liposomes; chemical shift perturbations Data_fig5 - Fig 5 - ThT for the splice variants incubated with DMPS at 30 degrees Celcius Data_fig6 - Fig 6 - ThT for the splice variants incubated with DMPS with a temperature jump Data_SI_fig3 - SI fig 3 - fluorescence polarisation of DMPS liposomes in the prescence of the different splice variants Data_SI_fig6 - SI fig 6 - ThT for the splice variants incubated with DLPS at 30 degrees Celcius 5. METHODS ---------- For full method details, see the associated publication or contact the corresponding authors.