1. ABOUT THE DATASET -------------------- Title: Dataset associated with "Third body wear of an all-polymer, PEEK-OPTIMA™-on-Ultra-High-Molecular-Weight Polyethylene total knee replacement" Creator(s): Raelene Cowie, Louise Jennings Organisation(s): Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds. UK Rights-holder(s):Copyright 2025 University of Leeds Publication Year: 2025 Description: This dataset contains material to supplement the experimental wear simulation study "Third Body Wear of an All-Polymer, PEEK-OPTIMA™- on-Ultra-High-Molecular-Weight Polyethylene Total Knee Replacement" Cite as: Raelene M Cowie, Louise M Jennings (2025): Dataset associated with "Third body wear of an all-polymer, PEEK-OPTIMA™-on-UHMWPE total knee replacement". University of Leeds [Dataset]. https://doi.org/10.5518/1644 Related publication: Raelene M Cowie, Jens Schwiesau, Thomas M. Grupp, Adam Briscoe, and Louise M. Jennings. 2025. "Third Body Wear of an All-Polymer, PEEK-OPTIMA™ on Ultra-High-Molecular-Weight Polyethylene Total Knee Replacement" Bioengineering 12, no. 3: 261. https://doi.org/10.3390/bioengineering12030261 Contact: r.cowie@leeds.ac.uk; l.m.jennings@leeds.ac.uk 2. TERMS OF USE --------------- Copyright 2025 University of Leeds. This dataset is licensed under a Creative Commons Attribution 4.0 International Licence: https://creativecommons.org/licenses/by/4.0/. 3. PROJECT AND FUNDING INFORMATION ---------------------------------- Partial funding from: Title: EPSRC Medical Technologies Innovation and Knowledge Centre Phase 2 Regenerative Devices Dates: Jun 15 - Jan 23 Funding organisation: EPSRC Grant no.: EP/N00941X/1 Partial funding from: Invibio Knees Ltd. 4. CONTENTS ----------- Please copy files into Excel: wear_volume.txt; Wear volume (mm3) of UHMWPE tibial components articulating against CoCr and PEEK femoral components tested in clean lubricant, lubricant with porcine bone particles and lubricant containing PMMA cement particles (Figure 2). wear_rate.txt; Wear rate (mm3/MC) of UHMWPE tibial components articulating against CoCr and PEEK femoral components tested in clean lubricant, lubricant with porcine bone particles and lubricant containing PMMA cement particles (Figure 2). surface_roughness.txt; Mean surface roughness (Ra) of femoral and tibial components pre-test, after 1MC tested in clean lubricant, 1MC tested in lubricant with porcine bone particles and 1MC in lubricant with PMMA cement (Table 2). additional_surface_roughness.txt; Additional surface roughness measurements of femoral and tibial components pre-test, after 1MC in clean lubricant, 1MC in lubricant with porcine bone particles and 1MC in lubricant with PMMA cement particles. bulk_lubricant_temperature.txt; Bulk lubricant temperature (°C) for each implant taken close to the articulating surface of the joint when tested in clean lubricant, with porcine bone particles and with PMMA cement particles (Table 3). supplementary_material.pdf; Supplementary data relating to the particle size distribution, particle images and additional surface topography measurements. 5. METHODS ---------- Porcine bone particles were prepared by dissecting cortical bone from porcine femurs, freezing the bone at -20 °C prior to grinding using a bladed grinder and sieving to generate particles within a size range of 500 – 1000 µm; for PMMA cement particles, the cement was prepared as per the manufacturers’ instruction and prepared in the same manner as for the bone particles. To assess the particle size, images were taken on an Alicona G5 optical microscope and analysed within the Alicona software. Experimental knee simulation study using a ProSim electromechanical (EM1) knee simulator (KS7) running under Leeds High kinematic conditions at rig running temperature. Gravimetric analysis of the UHMWPE tibial components was carried out prior to the start of the study and after each subsequent 0.3MC wear simulation using a Mettler Toledo XP205 digital microbalance with a readability of 5 d.p. The surface topography of the articulating surface was carried out prior to the start of the study and every 1MC using a Taylor Hobson PGI800 contacting Form Talysurf. For the femoral components, 5 measurements were taken per condyle in a medial-lateral direction through the flexion range; for the tibial components, 4 measurements were taken per condyle perpendicular to the direction of sliding. The bulk lubricant temperature was assessed every 0.3MC. All data was processed sing MS Excel (version 2408) with the mean with either the 95% confidence limits or standard deviation presented as appropriate. Statistical analysis was carried out in MS Excel and a one-way ANOVA was used to compare PEEK to CoCr with significance taken at p<0.05. Initially, 1MC wear simulation was carried out under clean (non-contaminated) conditions followed by a subsequent 1MC with porcine bone particles added to the lubricant (5 mg/ml) and 1MC with PMMA cement added to the lubricant (5 mg/ml). Jens Schwiesau (co-author) - person involved in study design Thomas M. Grupp (co-author) - person involved in study design Adam Briscoe (co-author) - person involved in study design Philip Wood (acknowledgement) – Laboratory manager, oversight of laboratory facilities including maintenance of simulators, advice on technical aspects of the project such as manufacturing. Detailed methods are available in: Cowie, R.M.; Schwiesau, J.; Grupp, T.M.; Briscoe, A.; Jennings, L.M. Third Body Wear of an All-Polymer, PEEK-OPTIMA™ on Ultra-High-Molecular-Weight Polyethylene Total Knee Replacement. Bioengineering 2025, 12, 261. https://doi.org/10.3390/bioengineering12030261