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Supporting data for "Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly"

Xu, Yong and Maya-Martinez, Roberto and Guthertz, Nicolas and Heath, George R. and Manfield, Iain W. and Breeze, Alexander L. and Sobott, Frank and Foster, Richard and Radford, Sheena E. (2022) Supporting data for "Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly". University of Leeds. [Dataset] https://doi.org/10.5518/1000

Dataset description

Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to study the mechanism of amyloid assembly of wild-type hIAPP and its more amyloidogenic natural variant S20G. We also report the discovery of two structurally distinct small-molecule modulators of hIAPP assembly.

Keywords: hIAPP aggregation, Chemical kinetics, modu
Subjects: C000 - Biological sciences > C700 - Molecular biology, biophysics & biochemistry > C790 - Molecular biology, biophysics & biochemistry not elsewhere classified
Divisions: Faculty of Biological Sciences > Astbury Centre for Structural Molecular Biology
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LocationType
https://doi.org/10.1038/s41467-022-28660-7Publication
https://eprints.whiterose.ac.uk/183086/Publication
License: Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited: 31 Jan 2022 07:43
URI: http://archive.researchdata.leeds.ac.uk/id/eprint/921

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