Research Data Leeds Repository

Exploring high aspect ratio gold nanotubes as cytosolic agents: structural engineering and uptake into mesothelioma cells - dataset

Ye, Sunjie and Azad, Arsalan A. and Chambers, Joseph E. and Beckett, Alison J. and Roach, Lucien and Moorcroft, Samuel C. T. and Aslam, Zabeada and Prior, Ian A. and Markham, Alexander F. and Coletta, Louise P. and Marciniak, Stefan J. and Evans, Stephen (2020) Exploring high aspect ratio gold nanotubes as cytosolic agents: structural engineering and uptake into mesothelioma cells - dataset. University of Leeds. [Dataset] https://doi.org/10.5518/879

Dataset description

The generation of effective and safe nanoagents for biological applications requires their physicochemical characteristics to be tunable, and their cellular interactions to be well characterized. Here, the controlled synthesis is developed for preparing high‐aspect ratio gold nanotubes (AuNTs) with tailorable wall thickness, microstructure, composition, and optical characteristics. The modulation of optical properties generates AuNTs with strong near infrared absorption. Surface modification enhances dispersibility of AuNTs in aqueous media and results in low cytotoxicity. The uptake and trafficking of these AuNTs by primary mesothelioma cells demonstrate their accumulation in a perinuclear distribution where they are confined initially in membrane‐bound vesicles from which they ultimately escape to the cytosol. This represents the first study of the cellular interactions of high‐aspect ratio 1D metal nanomaterials and will facilitate the rational design of plasmonic nanoconstructs as cytosolic nanoagents for potential diagnosis and therapeutic applications.

Subjects:	F000 - Physical sciences > F300 - Physics
Divisions:	Faculty of Engineering and Physical Sciences > School of Chemical and Process Engineering Faculty of Engineering and Physical Sciences > School of Physics and Astronomy
Related resources:	Location Type https://doi.org/10.1002/smll.202003793 Publication http://eprints.whiterose.ac.uk/165600/ Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	30 Oct 2020 14:47
URI:	http://archive.researchdata.leeds.ac.uk/id/eprint/765
Additional details Additional details Creators: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Ye, Sunjie https://orcid.org/0000-0001-5152-5753 University Of Leeds https://doi.org/10.13039/501100000777 crossref Azad, Arsalan A. https://orcid.org/0000-0003-4890-9662 Cambridge Institute for Medical Research https://doi.org/10.13039/501100000580 crossref Chambers, Joseph E. https://orcid.org/0000-0003-4675-0053 Cambridge Institute for Medical Research https://doi.org/10.13039/501100000580 crossref Beckett, Alison J. https://orcid.org/0000-0001-8377-325X University of Liverpool https://doi.org/10.13039/501100000836 crossref Roach, Lucien https://orcid.org/0000-0002-9166-6662 University Of Leeds https://doi.org/10.13039/501100000777 crossref Moorcroft, Samuel C. T. https://orcid.org/0000-0002-4028-2124 University Of Leeds https://doi.org/10.13039/501100000777 crossref Aslam, Zabeada University Of Leeds https://doi.org/10.13039/501100000777 crossref Prior, Ian A. https://orcid.org/0000-0002-4055-5161 University of Liverpool https://doi.org/10.13039/501100000836 crossref Markham, Alexander F. https://orcid.org/0000-0002-6639-3199 University Of Leeds https://doi.org/10.13039/501100000777 crossref Coletta, Louise P. University Of Leeds https://doi.org/10.13039/501100000777 crossref Marciniak, Stefan J. https://orcid.org/0000-0001-8472-7183 Cambridge Institute for Medical Research https://doi.org/10.13039/501100000580 crossref Evans, Stephen https://orcid.org/0000-0001-8342-5335 University Of Leeds https://doi.org/10.13039/501100000777 crossref Type of data: Dataset Research funders: British Lung Foundation, Victor Dahdaleh Foundation, Medical Research Council, Cambridge BRC, Royal Papworth Hospital, Apha1‐Foundation, Health Services and Delivery Research Programme, EPSRC, MRC Grant numbers: MIC‐2016‐004, EP/EP/P023266/1, MR/L01629X, MR/R009120/1 Publication date: 2020 Resource language: English Metadata language: English Publisher: University of Leeds Last Modified: 30 Oct 2020 23:35

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Data

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