Research Data Leeds Repository

Data associated with 'Combined flow-focus and self-assembly routes for the formation of lipid stabilized oil-shelled microbubbles'

Churchman, Adam H. (2018) Data associated with 'Combined flow-focus and self-assembly routes for the formation of lipid stabilized oil-shelled microbubbles'. University of Leeds. [Dataset] https://doi.org/10.5518/153

Dataset description

The data presented here supports the results presented in the associated manuscript on the production of Oil Layer Inside Microbubbles and the conformation of the presence of their oil component. Briefly: Microbubbles (MBs) are used medically as contrast agents for ultrasound imaging and are being developed for the delivery of water soluble drugs. However, many new therapeutics require hydrophobic drug delivery systems. This study presents a new method to produce MBs coated with an inner oil layer (OLI-MBs) capable of encapsulating hydrophobic drugs and suitable for targeted, triggered release. This new method utilises high control flow-focus microfluidics with lipid oil nanodroplet self-assembly and spreading at gas-aqueous interfaces. OLI-MBs were produced with diameters of 2.4 ± 0.3 μm (standard deviation 1.6 μm) and at concentrations up to 10^6 bubbles/ml.

Keywords:	microbubbles; microfluidics; drug-delivery; hydrophobic; lipid-coated; oil-shelled
Subjects:	F000 - Physical sciences > F300 - Physics > F350 - Medical physics
Divisions:	Faculty of Engineering and Physical Sciences > School of Physics and Astronomy
Related resources:	Location Type http://doi.org/10.1038/micronano.2017.87 Publication http://eprints.whiterose.ac.uk/128511/ Publication http://etheses.whiterose.ac.uk/19585/ Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	13 Mar 2018 21:05
URI:	http://archive.researchdata.leeds.ac.uk/id/eprint/327
Additional details Additional details Creators: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Churchman, Adam H. https://orcid.org/0000-0001-8826-7583 University Of Leeds https://doi.org/10.13039/501100000777 crossref Type of data: Dataset Research funders: EPSRC Grant numbers: EP/K023845/1 Publication date: 2018 Resource language: English Publisher: University of Leeds Contact Email Address: a.h.churchman09@leeds.ac.uk Last Modified: 22 Mar 2018 09:27

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Data

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Raw data to accompany figure 9 [81MB] Raw data to accompany figure 9 [81MB] Raw data to accompany figure 9 [81MB] Visible to: Anyone File name: Figure_S1.zip Content type: Data Mime-Type: application/zip License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 81MB