Research Data Leeds Repository

Dataset associated with Passive Pico-injection Enables Controlled Crystallization in a Droplet Microfluidic Device

Li, Shunbo (2017) Dataset associated with Passive Pico-injection Enables Controlled Crystallization in a Droplet Microfluidic Device. University of Leeds. [Dataset] https://doi.org/10.5518/234

Dataset description

Segmented flow microfluidic devices offer an attractive means of studying crystallisation processes. However, while they have been widely employed for protein crystallisation, there are few examples of their use for sparingly-soluble compounds due to problems with rapid device fouling and irreproducibility over longer run-times. This article presents a microfluidic device which overcomes these issues, where this is constructed around a novel design of “pico-injector” that facilitates direct injection into flowing droplets. Exploiting a Venturi junction to reduce the pressure within the droplet, we show that passive injection of solution from a side-capillary can be achieved in the absence of an applied electric field. The operation of this device was demonstrated for calcium carbonate, where highly reproducible results were obtained over long run-times at high supersaturations. This compares with conventional devices that use a Y-junction to achieve solution loading, where in-channel precipitation of calcium carbonate occurred even at low supersaturations. This work not only opens the door to the use of microfluidics to study the crystallisation of low solubility compounds, but the simple design of a passive pico-injector will find wide utility in areas including multi-step reactions and investigation of reaction dynamics. And the useful dataset were deposited here.

Keywords:	Calcium Carbonate, Microfluidics, Picoinjector, Device Fouling, Crystallization
Subjects:	F000 - Physical sciences > F100 - Chemistry > F180 - Analytical chemistry
Divisions:	Faculty of Engineering and Physical Sciences > School of Chemistry
Related resources:	Location Type https://doi.org/10.1002/smll.201702154 Publication http://eprints.whiterose.ac.uk/119960/ Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	15 Aug 2017 14:06
URI:	http://archive.researchdata.leeds.ac.uk/id/eprint/236
Additional details Additional details Creators: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Li, Shunbo https://orcid.org/0000-0001-5297-9079 Type of data: Dataset Research funders: Engineering and Physical Sciences Research Council (EPSRC) Grant numbers: EP/L015005/1 Publication date: 2017 Resource language: English Publisher: University of Leeds Contact Email Address: chmslic@leeds.ac.uk Last Modified: 07 Sep 2017 08:02

Files

Documentation

Readme.txt [1kB] Readme.txt [1kB] Readme.txt [1kB] Visible to: Anyone File name: Readme.txt Content type: Documentation Mime-Type: text/plain License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 1kB

Data

Experiment set-up [329kB] Experiment set-up [329kB] Experiment set-up [329kB] Visible to: Anyone File name: Setup.jpg Content type: Data Mime-Type: image/jpeg License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 329kB

Injection video [1MB] Injection video [1MB] Injection video [1MB] Visible to: Anyone File name: Injection-demo.mp4 Content type: Data Mime-Type: video/mp4 License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 1MB

Injection video [1MB] Injection video [1MB] Injection video [1MB] Visible to: Anyone File name: secondary_droplets.mp4 Content type: Data Mime-Type: video/mp4 License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 1MB

Injection video [1MB] Injection video [1MB] Injection video [1MB] Visible to: Anyone File name: CaCO3_crystallization.mp4 Content type: Data Mime-Type: video/mp4 License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 1MB

Injection volume calibration (.opj) [738kB] Injection volume calibration (.opj) [738kB] Injection volume calibration (.opj) [738kB] Visible to: Anyone File name: picoinjec-cal.opj Content type: Data License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 738kB

Raman spectra (.opj) [79kB] Raman spectra (.opj) [79kB] Raman spectra (.opj) [79kB] Visible to: Anyone File name: ACC-vat-Cal-std.opj Content type: Data License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 79kB

Raman spectra (.opj) [78kB] Raman spectra (.opj) [78kB] Raman spectra (.opj) [78kB] Visible to: Anyone File name: ACC-in-droplet.opj Content type: Data License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 78kB

Raman spectra (.opj) [86kB] Raman spectra (.opj) [86kB] Raman spectra (.opj) [86kB] Visible to: Anyone File name: Raman-vat-Cal-5Ca-5CO3.opj Content type: Data License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 86kB

Injection volume calibration (.xlsx) [8kB] Injection volume calibration (.xlsx) [8kB] Injection volume calibration (.xlsx) [8kB] Visible to: Anyone File name: Calibration_injection_volume.xlsx Content type: Data Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 8kB

Raman spectra (.xlsx) [146kB] Raman spectra (.xlsx) [146kB] Raman spectra (.xlsx) [146kB] Visible to: Anyone File name: Raman_spectra.xlsx Content type: Data Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet License: Creative Commons Attribution 4.0 International (CC BY 4.0) File size: 146kB