Research Data Leeds Repository

Data associated with 'Inducing protein aggregation by extensional flow'

Dobson, John and Kumar, Amit and Willis, Leon and Higazi, Daniel and Turner, Richard and Lowe, David and Tuma, Roman and Ashcroft, Alison and Radford, Sheena and Kapur, Nikil and Brockwell, David, MedImmune Ltd (2017) Data associated with 'Inducing protein aggregation by extensional flow'. University of Leeds. [Dataset] https://doi.org/10.5518/125

Dataset description

This dataset contains a major part of the data shown within the manuscript (NTA and Pelleting for all proteins and DLS data for BSA).

Keywords:	Protein aggregation, biophysics, applied fluid mechanics, biotechnology
Subjects:	C000 - Biological sciences > C700 - Molecular biology, biophysics & biochemistry C000 - Biological sciences > C700 - Molecular biology, biophysics & biochemistry > C770 - Biophysical science H000 - Engineering > H100 - General engineering > H140 - Mechanics > H141 - Fluid mechanics
Divisions:	Faculty of Biological Sciences > Astbury Centre for Structural Molecular Biology Faculty of Biological Sciences > School of Molecular and Cellular Biology Faculty of Engineering and Physical Sciences > School of Mechanical Engineering Faculty of Engineering and Physical Sciences > School of Mechanical Engineering > Institute of Thermofluids
Related resources:	Location Type http://doi.org/10.1073/pnas.1702724114 Publication http://eprints.whiterose.ac.uk/114410/ Publication
License:	Creative Commons Attribution 4.0 International (CC BY 4.0)
Date deposited:	06 Apr 2017 17:54
URI:	http://archive.researchdata.leeds.ac.uk/id/eprint/138
Additional details Additional details Creators: Creators ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Dobson, John Kumar, Amit Willis, Leon https://orcid.org/0000-0001-6616-3716 Higazi, Daniel Turner, Richard Lowe, David Tuma, Roman https://orcid.org/0000-0003-0047-0013 Ashcroft, Alison https://orcid.org/0000-0002-1676-123X Radford, Sheena https://orcid.org/0000-0002-3079-8039 Kapur, Nikil Brockwell, David https://orcid.org/0000-0002-0802-5937 Corporate creators: MedImmune Ltd Type of data: Dataset Contributors: Contribution Name ORCID Other ID Email Primary affiliation Primary affiliation ID Primary affiliation ID type Secondary affiliation Secondary affiliation ID Secondary affiliation ID type Higazi, Daniel Turner, Richard Lowe, David Research funders: MedImmune Ltd, University of Leeds, EPSRC, ERC, GlaxoSmithKline Ltd and Royal Academy of Engineering Collection period: Date from Date to 1 October 2013 31 December 2016 Grant numbers: EP/I033270/1, FP7/2007-2013 Grant Agreement 32240 Publication date: 2017 Resource language: English Metadata language: English Publisher: University of Leeds Contact Email Address: n.kapur@leeds.ac.uk Last Modified: 20 Apr 2017 11:14

Files

Data

Figure 2 [18kB] Figure 2 [18kB] Figure 2 [18kB] Visible to: Anyone File name: Fig2.zip Content type: Data Description: Data shown in bar charts in Figure 2B, D and E Mime-Type: application/zip File size: 18kB

Figure 3 [12kB] Figure 3 [12kB] Figure 3 [12kB] Visible to: Anyone File name: Fig3.zip Content type: Data Description: Data shown in bar charts in Figure 3A and F Mime-Type: application/zip File size: 12kB

Figure 4 [8kB] Figure 4 [8kB] Figure 4 [8kB] Visible to: Anyone File name: Fig4C.xlsx Content type: Data Description: Data shown in the bar chart in Figure 4C. Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 8kB

Figure S3 [60kB] Figure S3 [60kB] Figure S3 [60kB] Visible to: Anyone File name: FigS3.zip Content type: Data Description: NTA analysis data in Figure S3A and DLS data in Figure S3B Mime-Type: application/zip File size: 60kB

Figure S4 [471kB] Figure S4 [471kB] Figure S4 [471kB] Visible to: Anyone File name: FigS4.zip Content type: Data Description: NTA analysis data shown in Figures S4A-G Mime-Type: application/zip File size: 471kB

Figure S5 [16kB] Figure S5 [16kB] Figure S5 [16kB] Visible to: Anyone File name: FigS5.zip Content type: Data Description: DLS data shown in Figure S5C and D Mime-Type: application/zip File size: 16kB

Figure S6 [9kB] Figure S6 [9kB] Figure S6 [9kB] Visible to: Anyone File name: FigS6.xlsx Content type: Data Description: DLS z-average radii data shown in Figure S6 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 9kB

Figure S8 [58kB] Figure S8 [58kB] Figure S8 [58kB] Visible to: Anyone File name: FigS8A.xlsx Content type: Data Description: NTA data shown in Figure S8A Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 58kB

Figure S9 [75kB] Figure S9 [75kB] Figure S9 [75kB] Visible to: Anyone File name: FigS9A.xlsx Content type: Data Description: NTA data shown in Figure S9A Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 75kB

Figure S10 [75kB] Figure S10 [75kB] Figure S10 [75kB] Visible to: Anyone File name: FigS10A.xlsx Content type: Data Description: NTA data shown in Figure S10A Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 75kB

Figure S11 [50kB] Figure S11 [50kB] Figure S11 [50kB] Visible to: Anyone File name: FigS11A.xlsx Content type: Data Description: NTA data shown in Figure S11A Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 50kB

Figure S12 [60kB] Figure S12 [60kB] Figure S12 [60kB] Visible to: Anyone File name: FigS12A.xlsx Content type: Data Description: NTA data shown in Figure S12A Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 60kB

Figure S14 [8kB] Figure S14 [8kB] Figure S14 [8kB] Visible to: Anyone File name: FigS14.xlsx Content type: Data Description: Data shown in bar chart in Figure S14 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet File size: 8kB